Royal Air Force Typhoon FGR4s have joined forces with French aircraft in a combined operation on an hidden munitions depot in Syria employed by the Daesh militant organization, per a report from the UK's MoD.
The facility, pinpointed through reconnaissance, was believed to be containing munitions and bombs, the statement said, and was positioned in mountains just north of the historic site of Palmyra in central Syria.
"The RAF jets employed Paveway IV guided bombs to strike a series of entry passages down to the facility... initial indications are that the objective was successfully hit," the MoD said.
There was no sign of any civilian impact in the strike conducted Saturday night and each participating jet returned safely, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager refuelling tanker.
IS - referred to as the so-called Islamic State - established militant control over large swathes of Iraq and Syria prior to its 2019 collapse.
"This action underscores the UK's leading role, and commitment to operate in unison with our allies, to eradicate any resurgence of IS and their dangerous and violent ideologies in the area," UK Defence Secretary the Defence Secretary said.
UK warplanes have carried out surveillance missions over Syrian airspace to "deter any attempted comeback" of Islamic State after its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I want to thank the personnel of British forces involved in this operation for their professionalism and their bravery," Healey said. "They were among numerous UK service members stationed over the holidays. This mission, to remove dangerous terrorists who threaten our security, demonstrates how UK forces are ready to step up, continuously, ensuring Britain's security domestically and powerful internationally."
In December, the United States armed forces conducted what it described as a "massive strike" on IS targets in Syria, after an assault claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations reports Daesh still has between 5,000 and 7,000 fighters in both countries.